在Foxp2-表达神经元上的Mu-阿片类受体淘汰会减少厌恶性抗酒精饮用
Harrison M Carvour1, Charlotte A E G Roemer1, D'Erick P Underwood1
1Department of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Pharmacology, biochemistry, and behavior
|December 8, 2024
概括
在Foxp2-表达神经元中删除片受体 (MORs) 减少了酒精消耗,增加了对酒精厌恶的敏感性. 这些发现表明,Foxp2表达神经元参与了强迫性饮酒.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 杏仁体和条形体中的片受体 (MOR) 对奖励和成至关重要.
- 福克斯p2是特定神经元群体的标记物 (间隔细胞和条状中等状神经元),表达与酒精消费相关的MOR.
研究的目的:
- 调查MORs在Foxp2表达神经元中与酒精有关的行为中的作用.
- 在Foxp2-表达神经元中删除MOR基因 (Oprm1) 的行为影响的特征.
主要方法:
- 在Foxp2-表达神经元中产生了Foxp2-Cre/Oprm1fl/fl小鼠 (雄性和雌性) 的MOR删除.
- 评估了抗厌恶的酒精消费 (间歇性访问任务),寻求糖糖奖励 (操作者响应),吗啡戒断厌恶 (CPA) 和运动活动.
主要成果:
- 在Foxp2-表达神经元中的MOR删除增加了对氨酸改酒精的敏感性.
- 带有MOR删除的小鼠消耗的酒精较少,并且显示出基线和吗啡诱导活性减少.
- 观察到减少寻求糖的趋势;对吗啡戒断的学习和厌恶没有受到影响.
结论:
- Foxp2表达神经元在增加酒精摄入量方面发挥着重要作用.
- 在这些神经元中删除MORs可能会减少强迫性饮酒行为.
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