奇托桑-泽因-伊卡林复合物调节双乳液阶段过渡,以增强吸收效率
Yifeng Shen1, Chunyan Fang2, Xiaopeng Huang1
1TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China.
International journal of biological macromolecules
|December 8, 2024
概括
这项研究创造了一种稳定的奇托桑-泽因-伊卡林复合物,用于增强双重乳液的输送. 这个复杂的改善了icariin.
科学领域:
- 材料科学 材料科学 材料科学
- 食品科学 食品科学 食品科学
- 生物技术是生物技术.
背景情况:
- 开发有效的输送系统对于像伊卡林这样的疏水化合物,对于提高其生物可访问性和有效性至关重要.
- 桑和烯是生物相容的聚合物,具有复杂形成和乳液稳定潜力.
- 与二进制系统相比,三进制复合体提供了先进的结构和功能特性.
研究的目的:
- 使用逆相沉来开发一种奇托桑-泽因-伊卡林三元复合物,以稳定双重乳液.
- 研究三元复合体的结构性,热性和接口性质.
- 为了评估从准备的双重乳液中获得的伊卡林的稳定性,体外消化和生物可访问性.
主要方法:
- 逆相沉被用来合成色素-zein-icariin三元复合物.
- 一步乳化被用来制备由三元复合体稳定的双乳液.
- 鉴定包括显微镜,粒子大小分析,热分析,接触角测量,体外消化和Caco-2细胞研究.
主要成果:
- 三元复合体形成了球形微观结构,尺寸分布均.
- 加入伊卡林降低了热稳定性和界面接触角度.
- 双乳液呈现多腔结构,在冷藏后凝固,并显示出增强的储存稳定性,但在应力 (NaCl,温度) 下增加滴滴大小.
- 在体外消化导致复杂的分解和伊卡林的释放,显著提高了Caco-2细胞的生物可访问性和吸收效率.
结论:
- 奇托桑-赛因-伊卡林三元复合物有效地稳定了双重乳液,改善了伊卡林的体外生物可访问性和吸收性.
- 该综合体展示了作为疏水生物活性化合物的输送系统的潜力.
- 这项研究为设计使用疏水性多变体复合体的先进输送系统提供了基础.
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