阿斯特拉加卢斯的多糖化物通过调节肠道微生物群和SCFA代谢来缓解由金黄色葡萄球菌感染扰乱的乳腺炎
Kefei Li1, Xin Ran2, Jiaxi Han2
1College of Animal Veterinary Medicine, Yunnan Agricultural University, Kunming, Yunnan 650201, China; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
International journal of biological macromolecules
|December 8, 2024
概括
阿斯特拉加卢斯多糖 (APS) 通过减少炎症和氧化应激,有效地治疗金黄色葡萄球菌乳腺炎. 它通过调节肠道微生物群来起作用,特别是丰富Ruminococcus bromii,以恢复血液-牛奶屏障.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 来自中国草药的多糖体通过肠道微生物群调节显示出治疗潜力.
- 这些化合物在乳腺炎症,氧化应激和在黄金葡萄球菌感染期间的血乳屏障保护中的作用尚不清楚.
- 了解肠-乳腺轴是确定有效的益生菌干预措施的关键.
研究的目的:
- 调查阿斯特拉加卢斯多糖 (Astragalus polysaccharide,简称APS) 在缓解金黄色葡萄球菌引起的乳腺炎症和氧化应激方面的疗效.
- 为了确定APS是否能保护受损的血液与乳液屏障 (BMB).
- 阐明APS对肠道微生物群调节在治疗效果中的作用.
主要方法:
- 大鼠模型的黄金葡萄球菌乳腺感染.
- 评估炎症反应,氧化应激标志物和BMB完整性.
- 肠道微生物枯竭和便微生物群移植 (FMT) 实验,以证实APS的肠道微生物群依赖性影响.
- 16S rRNA测序用于肠道微生物组成分析.
主要成果:
- APS有效地减轻了乳腺中的金黄色葡萄球菌感染,抑制了炎症,并减少了氧化应激.
- 治疗APS恢复了血液-牛奶屏障 (BMB) 的完整性.
- 在肠道微生物群中,APS显著丰富了Ruminococcus bromii,从而增强了短链脂肪酸 (SCFA) 产量 (乙酸盐和丁酸盐).
结论:
- 阿斯特拉加卢斯多糖 (APS) 为 Staphylococcus aureus 诱导的乳腺炎提供了一种新的治疗策略.
- 通过调节肠道微生物群,APS表现出保护作用,特别是促进Ruminococcus bromii和SCFA生产.
- 这些发现支持使用APS作为益生菌和Ruminococcus bromii作为乳腺炎治疗和预防的益生菌.
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