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基于便免疫化学测试和风险评估的结肠直肠癌查:一项基于人口的研究,包括中国200万参与者.

Dong Hang1, Chen Zhu2, Xiaolin Yang1

  • 1Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University.

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概括

结合便免疫化学测试 (FIT) 和基于问卷的风险评估 (QRA),有效地识别了患结直肠癌 (CRC) 前体的高风险个人. 那些FIT和QRA阳性的人需要立即进行结肠镜检测以检测晚期瘤.

关键词:
结肠镜检查是一次结肠镜检查.结肠直肠癌是一种癌症.便免疫化学试验风险评估 风险评估 风险评估查检查 查检查 查检查

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科学领域:

  • 胃肠病学 胃肠病学
  • 在瘤学瘤学.
  • 公共卫生 公共卫生

背景情况:

  • 便免疫化学测试 (FIT) 是一种常见的结直肠癌 (CRC) 查工具.
  • 在CRC查中,FIT与基于问卷的风险评估 (QRA) 的联合表现尚未得到充分证实.
  • 在查期间检测到的不同CRC前体的风险因素需要进一步进行比较分析.

研究的目的:

  • 评估FIT与QRA结合在基于人口的大规模CRC查中的实际表现.
  • 为了比较与FIT和QRA结果相关的合规性,检测率和结肠镜工作量.
  • 为了确定常规腺瘤和状息肉的危险因素.

主要方法:

  • 一项基于中国人口的CRC查研究,涉及2,120,340名参与者.
  • 参与者完成了FIT和QRA;建议对FIT或高QRA得分进行结肠镜检查.
  • 合规性分析,检测率,结肠镜检查工作量以及腺瘤和状息肉的危险因素.

主要成果:

  • 在FIT (+) 和QRA (+) 组 (41.4%),FIT (+) 和QRA (-) (38.7%) 和FIT (-) 和QRA (+) (16.4%) 组中,结肠镜合规度最高.
  • 晚期瘤检测率为18.2% (FIT+/QRA+),13.2% (FIT+/QRA-),9.3% (FIT-/QRA+) 的情况.
  • 增加的BMI,吸烟,酒精,红肉和2型糖尿病与更高的晚期腺瘤和状息肉的风险有关;蔬菜摄入量显示反向关联.

结论:

  • FIT和QRA可以协同识别患结直肠晚期瘤的高风险个体.
  • 检测FIT和QRA阳性的人需要立即进行结肠镜评估.
  • 可修改的生活方式因素可以补充查策略来预防CRC前体.