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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
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For any given polymer, the weight average molecular weight (Mw) is higher than, if not equal to, the number average molecular weight (Mn). The only situation in which the weight average molecular weight and the number average molecular weight are equal is when a polymer consists only of chains with equal molecular weight. However, this never happens in a synthetic polymer, since it is difficult to control the polymerization process up to a molecular level with accuracy to a hundred percent.
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Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
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单一马尔托德素颗粒的特性与粉末功能之间的联系

Regis Badin1, Claire Gaiani2, Stephane Desobry2

  • 1Université de Lorraine, Laboratoire d'Ingénierie des Biomolécules (LIBio), Nancy F-54000, France; School of Agriculture and Food Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia.

Carbohydrate polymers
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概括
此摘要是机器生成的。

这项研究表明,酸盐等效 (DE) 和玻璃化转变如何影响马尔托德克斯粉的特性. 环境条件的变化和玻璃过渡显著影响单颗粒的行为和散装粉末的特性.

关键词:
原子力显微镜 原子力显微镜食品粉末是一种食品粉末.玻璃过渡 玻璃过渡 玻璃过渡马尔托德克斯特林 (Maltodextrins) 是一种乳制品.多尺度研究多尺度研究重建的重建是为了重建.表面表征表征表征的表征表征.

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科学领域:

  • 食品科学与技术 食品科学与技术
  • 材料科学 材料科学 材料科学
  • 物理化学 物理化学

背景情况:

  • 马尔托德克斯是重要的食品成分,影响产品的质地和稳定性.
  • 了解它们在粒子水平上的行为是优化食品配方的关键.

研究的目的:

  • 为了研究单一麦芽素颗粒表面特性和技术功能行为之间的联系.
  • 为了阐明德克斯特等效 (DE) 和玻璃化转换对马尔托德克斯特林特性的影响.

主要方法:

  • 同焦激光扫描显微镜 (CLSM) 和环境原子力显微镜 (AFM) 用于单颗粒分析.
  • 扫描电子显微镜 (SEM) 和特定表面积 (SSA) 在不同相对湿度 (RH) 下进行测量.

主要成果:

  • 湿性质与DE直接相关;较高的DE马尔托德克斯特林表现出更快的湿.
  • 玻璃过渡显著影响表面弹性和毛细血管粘附,改变粒子形态.
  • 随着RH的增加和接近玻璃过渡,Young的模量下降和毛细血管力的增加被观察到.

结论:

  • 玻璃过渡是影响马尔托德素颗粒形态的关键因素,导致表面光滑和状状态的胀.
  • 环境条件和玻璃过渡是马尔托德克斯特林粉体散装行为的关键决定因素.