MWCNTs-Beta-Cyclodextrin-reduced graphene oxide基于凝的电化学传感器,用于在人类汗液样本中同时检测多巴胺和尿酸
Muthui Martin Mwaurah1, Jayaraman Mathiyarasu1, A M Vinu Mohan2
1Electrodics and electrocatalysis Division, CSIR- Central Electrochemical Research Institute, Karaikudi, 630 003, Tamil Nadu, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Carbohydrate polymers
|December 8, 2024
概括
这项研究介绍了一种灵活,低成本的传感器,用于检测汗水中的多巴胺 (DA) 和尿酸 (UA). 新型传感器使用复合凝进行准确和同时分析,有助于疾病诊断.
科学领域:
- 电化学 电化学 电化学
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 准确检测多巴胺 (DA) 和尿酸 (UA) 对于诊断神经系统疾病和痛风至关重要.
- 目前用于DA和UA检测的方法可能是复杂和昂贵的.
- 汗液分析为监测这些生物标志物提供了一个非侵入性的替代方案.
研究的目的:
- 开发一种灵敏,便宜,灵活的丝网打印传感器,用于在汗水中同时确定DA和UA.
- 使用一种新型的复合凝,其中包括β-cyclodextrin (βCD),减少的氧化石墨烯 (rGO) 和多壁碳纳米管 (MWCNT).
- 为了验证传感器的性能对潜在的诊断应用.
主要方法:
- 通过βCD的自我聚合合成一个MWCNTs-βCD-rGO复合凝.
- 使用复合凝制造柔性丝印电极 (SPE).
- 使用包括XRD,TGA,FTIR,UV-Vis,1H NMR,FESEM,XPS和光学显微镜在内的技术进行凝的表征.
- 在人造和人类汗液样本中电化学检测DA和UA.
主要成果:
- 传感器在临床相关范围内显示了DA (LoD 0.08 μM) 和UA (LoD 0.078 μM) 的高灵敏度.
- 对DA (0.2516μM) 和UA (50700μM) 建立了线性检测范围,相关系数高 (R2 > 0.986).
- 在人类汗液样本中同时检测到DA和UA,显示出出色的重复性和令人满意的恢复率.
结论:
- 开发的灵活的丝网打印传感器提供了一个有希望的,具有成本效益的平台,用于在汗水中非侵入性监测DA和UA.
- 该MWCNTs-βCD-rGO复合凝可实现选择性生物识别和对目标分析物的敏感检测.
- 这种传感器技术在神经退行性疾病和痛风的早期诊断和管理中具有潜在的应用.
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