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Updated: Jun 5, 2025

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乙转移酶NAT10通过调节前列腺癌中CD8+ T细胞活性来促进免疫抑制的微环境

Ji Liu1,2, Zhuoran Gu1,2, Libin Zou1,2

  • 1Department of Urology, School of Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, China.

Molecular biomedicine
|December 8, 2024
PubMed
概括

N-乙转移酶10 (NAT10) 促进前列腺癌的生长和侵袭. 它通过CCL25/CCR9通路抑制CD8+T细胞活性,形成免疫抑制瘤微环境并阻碍免疫治疗.

关键词:
在 Ac4C 乙化过程中,免疫微环境是一个微环境.免疫治疗是一种免疫疗法.前列腺癌是什么意思 前列腺癌是什么意思

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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