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伊诺图祖马布 (ozogamicin) 用于预防唐氏综合征和复发性急性淋巴细胞白血病的男孩的复发

Atsushi Kohso¹, Hidemi Toyoda², Ryo Hanaki¹

¹Department of Pediatrics, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

International journal of hematology

|December 8, 2024

概括

伊诺图祖马布奥佐加米辛 (InO) 在患有唐氏综合征和复发的B细胞前体急性淋巴细胞白血病 (BCP-ALL) 的儿童中有效维持缓解. 这种毒性较低的策略为无法接受干细胞移植的患者提供了替代方案.

科学领域:

血液学血液学血液学
在瘤学瘤学.
儿科瘤学儿科瘤学

背景情况:

唐氏综合征 (DS) 增加了B细胞前体急性淋巴细胞白血病 (BCP-ALL) 的风险,复发率和治疗毒性.
针对复发性/耐药性DS-ALL的异构造血干细胞移植 (allo-HCT) 由于复发性和移植相关死亡率高,结果不佳.
新的,少有毒的治疗策略对于改善DS-ALL的结果至关重要.

研究的目的:

为了评估单剂伊诺图祖马布 (inotuzumab) 奥佐加米辛 (InO) 作为维持治疗的疗效.
评估INO作为BCP-ALL患者,特别是那些患有唐氏综合征,不能接受allo-HCT的较少毒性替代品.
报告一个患有DS和复发BCP-ALL的儿童在使用INO维护时持续缓解的病例.

主要方法:

一个患有唐氏综合征的孩子的病例报告和BCP-ALL的第二次复发.
用单剂伊诺图祖马布 (inotuzumab) 奥佐加米辛 (InO) 作为维持疗法的治疗.
在整个治疗期间监测完全缓解状态.

主要成果:

患有DS和复发的BCP-ALL的孩子实现并保持了完全缓解.
单剂的InO疗法在预防后续复发方面被证明是有效的.
治疗被耐受,这表明与强化疗法相比,治疗毒性较低.

结论:

单剂伊诺图祖马布 (inotuzumab) 维护奥佐加米辛 (InO) 是一种可行的,毒性较低的治疗选择.
InO可以帮助预防复发/耐药BCP-ALL患者的复发,特别是那些不符合alo-HCT资格的唐氏综合征患者.
这一战略提供了一种有希望的方法来改善这种高风险患者群体的治疗结果.

关键词:

B细胞前体急性淋巴细胞白血病.伊诺图祖马布 (inotuzumab) 是一种奥佐加米辛的药物.维护化疗是维护化疗.复发复发的情况

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