婴儿便衍生的FWJL-4减轻实验性死性肠球炎通过酸盐生产
Li-Long Pan1, Yudong Sun1, Xiaoliang Dong1
1Department of Neonatology, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Gut microbes
|December 8, 2024
概括
一种新型益生菌Lactobacillus gasseri FWJL-4通过增强肠道屏障功能来保护早产婴儿免受死角性肠球炎 (NEC) 的侵害. 这种保护与乙酸盐的增加产生有关,该乙酸盐可保护肠道细胞并抑制细胞死亡.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 新生儿科学 新生儿科学
背景情况:
- 结核性肠球炎 (NEC) 是早产婴儿的严重肠道疾病,死亡率高.
- 肠道失调症越来越多地与NEC的发展有关.
- 益生菌显示出预防NEC的潜力,但特定菌株需要进一步调查.
研究的目的:
- 评估一种新型益生菌菌株Lactobacillus gasseri FWJL-4在预防NEC方面的有效性.
- 阐明L. gasseri FWJL-4对NEC的保护作用的潜在机制.
主要方法:
- 乳杆菌气菌FWJL-4从健康婴儿便中分离出来.
- 该研究评估了益生菌对肠道屏障功能和NEC保护在模型中的影响.
- 分析了肠道酸盐水平,亡,杯细胞,肠细胞和GPR41/GPR43激活.
主要成果:
- L. gasseri FWJL-4显著增强了肠道屏障功能,并对NEC进行了保护.
- 益生菌增加了肠道酸盐水平,仅酸盐补充剂就减轻了NEC.
- L. gasseri FWJL-4通过酸盐生产和GPR41/GPR43激活抑制了亡并保存了杯状细胞和肠细胞.
结论:
- 在早产婴儿中,Lactobacillus gasseri FWJL-4提供了对NEC的大量保护.
- 升高的肠酸是益生菌保护作用的关键媒介.
- 益生菌诱导的酸盐生产为预防NEC提供了一个有前途的治疗策略.
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