在内血管治疗后,TyG指数对大血管闭合性中风的影响
Wei Sun1, Huixin Shen1, Xiao Wu1
1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
CNS neuroscience & therapeutics
|December 9, 2024
概括
甘油三糖 (TyG) 指数与急性缺血性中风患者在内血管治疗后的较差结果有关. 较高的TyG指数水平预测功能表现不佳,症状性内出血和死亡率.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 伴有大血管封闭 (LVO) 的急性缺血性中风 (AIS) 需要及时进行内血管治疗 (EVT).
- 确定EVT后临床结果的预测标记对于患者管理至关重要.
- 甘油三糖指数 (TyG) 是胰岛素抵抗的标志物,已成为各种心血管疾病的潜在预后因素.
研究的目的:
- 调查三甘-葡萄糖 (TyG) 指数与接受EVT的LVO诱导的AIS患者的临床结果之间的关联.
- 评估TyG指数在预测功能不良结果,早期神经系统恶化,症状性内出血 (sICH) 和90天死亡率方面的作用.
- 评估TyG指数是否改善了EVT后不良结果的传统因素的风险预测.
主要方法:
- 一个单一中心的回顾性队列研究包括424名患有AIS和LVO的患者,他们接受了EVT.
- 患者根据他们的TyG指数进行分层,该指数是根据禁食时的甘油三和葡萄糖水平计算的.
- 使用后勤回归,限制立方线 (RCS) 和接收器运行特征 (ROC) 曲线分析来评估TyG指数和临床结果之间的关系.
主要成果:
- 较高的TyG指数水平与更糟糕的90天功能结果 (p=0.006),症状性内出血 (sICH) (p=0.002) 和90天死亡率 (p<0.05) 有关.
- RCS建模表明,TyG指数与糟糕的结果,SICH和死亡率之间存在线性关系.
- 纳入TyG指数的模型显示,与传统风险因素单独 (AUC=0.824) 相比,对不良结果 (AUC=0.845) 的预测性能优越.
结论:
- 较高的TyG指数是EVT后LVO诱导的AIS患者不良临床结果的独立预测指标.
- 泰格指数显著提高了这种患者群体中不良结果的已确定的风险因素的预测能力.
- 该TyG指数作为一个有价值的预后生物标志物在AIS患者治疗EVT.
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