测量系统性红斑狼的脆弱性
Patricia Katz1, Maria Dall'Era1, Laura Plantinga1
1University of California San Francisco, San Francisco, California.
Arthritis care & research
|December 9, 2024
概括
系统性红斑狼 (SLE) 的不同脆弱性测量结果显示出不同的一致性,但通常预测健康状况不佳. 系统性狼国际合作诊所脆弱性指数 (SLICC-FI) 显示,SLE患者与健康结果的相关性最为一致.
科学领域:
- 风湿病学和老年病学
- 临床流行病学临床流行病学
背景情况:
- 脆弱性越来越被认为是系统性红斑狼 (SLE) 的重要因素.
- 存在多种工具来评估脆弱性,但它们在SLE中的一致性和预测价值尚未完全理解.
研究的目的:
- 评估SLE患者不同脆弱度量之间的一致性.
- 确定每个脆弱度量与横截面和纵向健康结果的关联.
主要方法:
- 利用了来自加利福尼亚狼流行病学研究的数据.
- 使用系统性狼国际合作诊所脆弱指数 (SLICC-FI),短物理性能电池 (SPPB) 和疲劳,抵抗,行走,疾病和体重减轻 (FRAIL) 尺度评估脆弱性.
- 患者报告结果测量信息系统物理功能10a (PF) 被用作代理;统计分析包括回归和Cox比例危险模型.
主要成果:
- 脆弱的流行率在各个措施之间有显著差异 (10.8%45.9%),略有或实质性一致 (k=0.170.63).
- 大多数脆弱性测量与横截面和纵向健康结果相关,除了SPPB.
- SLICC-FI显示了最一致的关联,其次是FRAIL和PF,将虚弱与住院治疗,残疾和认知障碍联系起来.
结论:
- 多种脆弱性评估工具可以识别患有SLE不良健康结果风险的患者.
- 选择脆弱性措施时,应考虑其预期的应用,简单性和易于实施.
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