在芯片上的容器模型中描述微泡介导的透性
Bram Meijlink1, Gonzalo Collado-Lara1, Kristina Bishard2
1Biomedical Engineering, Department of Cardiology, Cardiovascular Institute, Erasmus MC, Wytemaweg 80, Rotterdam, 3015 CN, The Netherlands.
Small (Weinheim an der Bergstrasse, Germany)
|December 9, 2024
概括
超声波微气泡通过增加血管透性来增强药物运输. 不同的超声波周期长度对透性和超声波产生不同的影响,有助于微泡介导药物递送的发展.
科学领域:
- 生物医学工程 生物医学工程
- 药物运输 药物运输 药物运输
- 声学医学是一种声学医学.
背景情况:
- 超声波激活的微气泡可以增加局部药物输送的血管透性.
- 精确的机制,包括超声波周期持续时间的影响,仍然不完全理解.
研究的目的:
- 为了研究由不同的超声波周期长度诱导的血管透性增加的机械差异.
- 开发和利用一个微血管在芯片上的模型来研究超声波-微泡相互作用.
- 为了比较短 (10周期) 与长 (1000周期) 的超声波治疗对血管透性和声波穿孔的影响.
主要方法:
- 开发一个带有外血管空间的无膜微血管在芯片上的模型.
- 使用2MHz超声波,在不同峰值负声压 (PNP) 时进行10或1000个周期的超声波.
- 评估血管透性变化,微血管活力和超声波,与微气泡行为相关.
主要成果:
- 在10到1000次超声波周期之间观察到明显的差异.
- 与1000个周期相比,10个周期的血管透率增加的较慢发病率.
- 较低的血管透性增加和sonoporation在750 kPa的10个循环与1000个循环.
- 较高的PNP值增加了血管透性,并且以更少的循环进行了超声波.
- 血管透率的增加与αvβ3向的微泡行为没有相关性,而超声波与微泡集群相关性.
结论:
- 开发的微血管在芯片上的模型为超声波介导的血管透性提供了机械的见解.
- 超声波周期长度显著影响了血管透性增加和声波穿孔的速度,程度和值.
- 这些发现支持微泡介导药物运输策略的安全和有效开发.
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