基于益生菌的矿物化生物材料生产抗菌酸奶
Gloria B Ramírez-Rodríguez1, Laura Sabio2, Laura Cerezo-Collado1
1Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Granada, Av. de Fuente Nueva, s/n, Granada, 18071, Spain.
Advanced healthcare materials
|December 9, 2024
概括
研究人员通过在原体内矿化益生菌来创造混合生物材料. 这保护了口服的细菌,并增强了它们的抗菌活性,为医疗保健和食品应用提供了新的可能性.
科学领域:
- 生物材料工程 生物材料工程
- 微生物学 微生物学
- 细胞生物学 细胞生物学
背景情况:
- 细胞矿化增强了对压力的弹性.
- 益生菌需要保护才能有效地通过口服输送.
- 现有的交付方法有其局限性.
研究的目的:
- 开发混合生物材料 (HLM) 来增强益生菌的口服输送.
- 为了保护益生菌,使用矿化原基质矩阵.
- 研究封装益生菌的生存能力和功能.
主要方法:
- 在益生菌 (Lactobacillus acidophilus) 周围的原纤维的同时自我组装和矿化.
- 通过apatite纳米薄膜涂层开发散装和单细胞封装.
- 对HLM代谢活性,酸奶发酵和抗菌性质对Pseudomonas aeruginosa和黄金葡萄球菌的评估.
- 在模拟胃液中对HLM保护的评估.
主要成果:
- 益生菌成功地集成到矿化原基质 (HLM) 中.
- 单细胞封装与阿帕纳米膜增强了益生菌的活力和活性.
- HLMs表现出代谢活性,发酵牛奶变成酸奶,并表现出抗菌性质.
- 在模拟的胃肠道条件下,HLM对益生菌提供了显著的保护.
结论:
- 混合生物材料提供了强大的益生菌口服输送的新策略.
- 矿化原基质增强了益生菌的弹性和功能.
- 这些HLM在先进的医疗保健材料和抗微生物益生菌食品中具有潜在的应用.
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