结合益生菌与CaO2纳米颗粒载荷的CoFeCe-LDH纳米片来重塑瘤微环境,用于精确的化学动力学疗法
Ruxue Si1, Tingting Hu2, Gareth R Williams3
1Beijing Institute of Clinical Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, P. R. China.
Advanced healthcare materials
|December 9, 2024
概括
这项研究开发了一种基于益生菌的新策略,通过化学动力学疗法 (CDT) 增强癌症治疗. 通过利用Lactobacillus acidophilus来修改瘤微环境,这种方法显著增加基生成,以改善瘤根除.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 化学动力学疗法 (CDT) 由于其特异性和低毒性,对癌症治疗具有前景.
- CDT的治疗疗效通常受到瘤微环境 (TME) 的限制,瘤微环境的特点是高pH,和低H2O2.
- 在TME中低基 (·OH) 产量阻碍了有效的癌细胞杀死.
研究的目的:
- 开发一种益生菌增强的化学动力学治疗平台,以改善癌症治疗.
- 为了利用Lactobacillus acidophilus修改TME并增强OH生成.
- 使用CaO2纳米颗粒和CoFeCe层叠的双氧化物纳米片制造高效的CDT剂.
主要方法:
- 合Lactobacillus acidophilus与装载在CoFeCe层的双氧化物纳米片 (CaO2/LDH@L. acidophilus) 上的CaO2纳米颗粒.
- 利用L. acidophilus的低氧热带性来增强瘤的积累.
- 调查益生菌代谢诱导的pH降低和在现场生成H2O2对OH生产的协同效应.
主要成果:
- 与CaO2/LDH@L. acidophilus相比,L. acidophilus显示瘤部位积累的增加.
- 综合方法显著促进了OH生成,导致癌细胞受到有效损害.
- 达到96.4%的瘤抑制率,比对照组高2.32倍.
结论:
- 益生菌可以作为瘤向平台,重塑TME以加强癌症治疗.
- 开发的CaO2/LDH@L. acidophilus系统有效地放大了反应性氧物种 (ROS) 的产生,以实现精确的CDT.
- 这一战略为高效和有针对性的癌症治疗提供了一个有希望的方法.
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