利用中介中心丘脑连接来个性化非侵入性神经调节目标
Cong Fu1,2,3, Zijian Feng3,4,5, Qiu Ge6,7,8
1Department of Neurosurgery, Epilepsy Center, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
CNS neuroscience & therapeutics
|December 9, 2024
概括
研究人员使用MRI绘制了中心中核功能连接 (CM-FC) 的地图,以个性化跨磁刺激 (TMS). 左主感觉运动皮层 (PSMC) 显示出可重现的连接性,为神经系统疾病提供了潜在的TMS目标.
科学领域:
- 神经科学是一个神经科学.
- 功能神经成像 功能神经成像
- 神经调节是一种神经调节.
背景情况:
- thalamus 的中心核 (CM) 对于唤醒,注意力,感官处理和运动控制至关重要.
- CM中的功能障碍与各种神经系统疾病有关,使其成为神经调节的目标.
- 针对CM的个性化精确的横磁性刺激 (TMS) 尚未报告.
研究的目的:
- 使用静止状态功能性MRI (rs-fMRI) 绘制基于CM的功能连接 (CM-FC).
- 开发一个个性化的TMS方案,针对神经疾病的CM.
- 为了确定可复制的CM-FC模式,以实现精确的神经调节.
主要方法:
- 在多个MRI扫描仪和会议 (人体连接组项目和杭州师范大学数据集) 中分析了健康受试者的CM-FC模式.
- 利用Pearson的相关性进行CM-FC评估和重叠指数来识别强大的组级集群.
- 应用流域图像细分到单个CM-FC地图,以精确确定单个集群,并将峰值voxel定义为潜在的个性化TMS目标.
主要成果:
- CMs与皮层区域,包括感觉运动,额头和部区域,表现出广泛的积极功能连接.
- 空间CM-FC模式在左和右CM之间高度一致.
- 在左CM的左主感官运动皮质 (PSMC) 中,确定了一个重叠指数为10的可复制组集群.
结论:
- 左PSMC表现出与左CM的可重现的功能连接.
- 在左PSMC中确定了个别峰值FC位置,可以作为一个可行的TMS目标.
- 这种方法促进了CM活动的间接调节,用于治疗CM相关的神经疾病.
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