在癌症患者接受佐莱德罗纳特治疗期间,急性功能衰竭
Wala Ben Kridis1, Mariem Ben Amor1, Afef Khanfir1
1Department of Medical Oncology, Habib Bourguiba Hospital University of Sfax, Sfax, Tunisia.
概括
在治疗骨转移时,急性功能衰竭与患者体重低和清除率低于60毫升/分钟有关. 这些因素对于治疗接受双酸盐的患者的管理至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 佐勒多尼酸是用于治疗骨转移的标准双酸盐.
- 评估急性功能衰竭 (ARF) 发生率和风险因素在酸治疗期间至关重要.
研究的目的:
- 为了确定急性功能衰竭 (ARF) 的发生率,在接受龙酸治疗的患者中.
- 为了确定与ARF相关的因素,在zoledronic酸治疗期间.
主要方法:
- 在哈比布·布尔吉巴大学医院进行了一项回顾性研究.
- 分析了2022年1月至2022年3月期间接受治疗的48名患者的数据.
- 使用病:改善全球结果 (KDIGO) 标准定义了急性功能衰竭.
主要成果:
- ARF的发病率为18.8% (9例),需要减少剂量.
- 低初始清除 (<60毫升/分钟) 和低体重 (<53.44公斤) 与ARF有显著的关联.
- 多变量分析证实了这些关联 (分别为p=0.003和p=0.01).
结论:
- 低体重和先前存在的功能障碍 (清除率<60毫升/分钟) 是酸治疗期间ARF的重要危险因素.
- 这些发现强调了仔细选择患者和监测功能的重要性.
- 根据功能和患者体重调整酸剂量可能会减轻ARF风险.
相关概念视频
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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
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However, dosage adjustments...
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