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Updated: Jun 5, 2025

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells
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Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells

Published on: June 10, 2022

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开发和应用一个无封闭的mRNA平台.

Xiaodi Zheng1, Biao Liu1, Peng Ni2

  • 1College of Bioengineering, National ''111'' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, Wuhan, China.

Annals of medicine
|December 9, 2024
PubMed
概括

一个新的未封闭的mRNA平台为疫苗和蛋白质替代疗法提供了经济和高效的替代方案. 这种平台利用内部核糖体进入部位 (IRES) 和尿素三酸盐 (UTP),成功诱导了针对SARS-CoV-2变种的强效中和抗体.

关键词:
在LNP中使用LNP.奥米克朗菌株中和的方法没有限制的mRNA.

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