COVID-19和瘤生育:精液中没有SARS-CoV-2,但炎症似乎影响了精子参数
Laure Chaput1,2, Hanae Pons-Rejraji1,2, Hélène Chabrolles3
1CHU Clermont-Ferrand, Service AMP-CECOS (Centre d'Etude et de Conservation des Œufs et du Sperme Humain), Clermont-Ferrand, France.
Journal of medical virology
|December 9, 2024
概括
在癌症患者的精液中没有检测到SARS-CoV-2. 然而,COVID-19感染对精液量,运动性和精液炎症的增加产生了负面影响,尽管患者无症状.
科学领域:
- 生殖医学 生殖医学
- 病毒学 病毒学
- 在瘤学瘤学.
背景情况:
- 随着COVID-19大流行,辅助生殖技术停止运行,癌症患者的生育能力得到优先保护.
- 精液中SARS-CoV-2的存在是正在进行的辩论和研究的主题.
研究的目的:
- 为了调查在接受生育保护的癌症患者的精子和精液等离子体中存在SARS-CoV-2的存在.
- 评估SARS-CoV-2感染对本种群的精液参数和精液细胞因子的影响.
主要方法:
- 一项多中心前性队列研究,涉及129名接受精子冷保存的癌症患者.
- 用RT-PCR和血清学测试63名患者的SARS-CoV-2感染.
- 通过ELISA进行了精液分析,细胞因子 (包括TNF-α) 水平.
主要成果:
- 所有测试的癌症患者的精液和精子中无法检测到SARS-CoV-2RNA.
- 与未感染个体相比,阳性COVID-19测试 (PCR+) 患者的射精量显著降低.
- 与血清阳性组相比,PCR+组的精子总和渐进性运动率较低.
- 在PCR+组的精液中发现了TNF-α的升高水平.
结论:
- 虽然在感染癌症患者的精液中没有发现SARS-CoV-2,但这种感染与对精子参数的有害影响有关.
- 由TNF-α增加表明的炎症可能是癌症患者COVID-19后感染后影响精子质量的潜在机制.
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