每个人都在使用生物结构,但如何找到一个人想要的结构?
Charles S Bond1, Joel L Sussman2
1University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.
Acta crystallographica. Section D, Structural biology
|December 9, 2024
概括
寻找特定的科学结构是具有挑战性的. 本评论建议改进,以便在科学数据库中更容易检索结构.
科学领域:
- 结构生物学 结构生物学
- 生物信息学是一种生物信息学.
- 科学数据库 科学数据库
背景情况:
- 在科学文献和数据库中定位特定的分子结构对研究人员来说可能是一个复杂和耗时的过程.
- 当前的搜索功能可能无法充分满足用户寻找特定结构信息的细微需求.
研究的目的:
- 评论在寻找特定科学结构时遇到的困难.
- 提出可行的策略,以提高结构数据的可访问性和可搜索性.
主要方法:
- 对现有搜索方法的定性评论和分析.
- 对结构生物学信息检索中的基于用户的挑战进行审查.
主要成果:
- 找到感兴趣的结构的易度有很大差异,往往比预期的更难.
- 在当前的搜索工具和数据库架构中发现的局限性阻碍了高效的结构发现.
结论:
- 解决结构检索方面的挑战需要采用多方面的方法,包括数据库优化和改进的搜索算法.
- 实施建议改进可以通过促进更快地访问关键结构数据,显著提高科学研究的效率.
相关概念视频
Levels of Organization
145.0K
Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
145.0K
Studying the Cytoskeleton
10.5K
The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...
10.5K
Evolutionary Relationships through Genome Comparisons
7.3K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.3K
Fixation and Sectioning
9.0K
Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens.
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
9.0K
Cryo-electron Microscopy
4.6K
Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
4.6K
Structural Organization of the Human Body: An Overview
38.7K
It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
38.7K


