在非洲推进药量测量 - - 从能力发展向创造就业机会的过渡
Goonaseelan Colin Pillai1,2,3, Samer Mouksassi3,4, Innocent G Asiimwe3,5
1Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
CPT: pharmacometrics & systems pharmacology
|December 9, 2024
概括
应用药量测量培训 (APT) 奖学金计划成功培训了非洲科学家在药量测量方面,促进了创造就业机会和留住人才. 这一举措对于推动非洲药物开发至关重要.
科学领域:
- 制药指标 (Pharmacometrics) 是一个指标.
- 药物开发 药物开发
- 临床数据分析 临床数据分析
背景情况:
- 由于培训和移民有限,非洲缺乏训练有素的药学专家.
- 在非洲缺乏强大的制药产品开发生态系统.
- 需要在药物开发的临床数据分析方面获得当地专业知识.
研究的目的:
- 审查应用药量测量培训 (APT) 奖学金计划在三年中的进展情况.
- 评估该计划在解决非洲药物计量师短缺问题的有效性.
- 鼓励合作,以加强当地临床数据分析能力.
主要方法:
- 该APT计划于2021年启动,为非洲博士级科学家和临床医生提供为期6个月的奖学金.
- 由Pharmacometrics Africa在合作伙伴支持下管理,专注于物流和赞助商联系.
- 包括创造就业机会的举措,如加入咨询团队或当地研究中心.
主要成果:
- 收到了177个申请,其中27个人在三年内完成了该计划 (41%为女性,平均年龄为35岁).
- 奖学员在13个数据分析项目中工作;六个在会议上发表或提交出版.
- 九名研究员在非洲的咨询团队或研究中心获得了职位.
结论:
- 该APT计划在培养技能,创造就业机会以及在非洲建立药理学专家的关键群体方面取得了成功.
- 该计划有助于留住人才,并加强当地对基于模型的药物开发能力.
- 合作对于非洲药物测量和药物开发的可持续发展至关重要.
相关概念视频
01:12Analysis of Population Pharmacokinetic Data
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Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
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01:20Pharmacokinetic Models: Overview
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Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
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01:06Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
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Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
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01:14Model Approaches for Pharmacokinetic Data: Compartment Models
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Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
Two primary types of compartment models are recognized: mammillary and catenary. The more...
Two primary types of compartment models are recognized: mammillary and catenary. The more...
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01:15Model Approaches for Pharmacokinetic Data: Physiological Models
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Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
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01:19Pharmacovigilance
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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
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