皮质灰质体积与食纤维和卡路里密度的关联:试点研究
Raghav Pallapothu1, Roger D Newman-Norlund1, Makayla Gibson1
1University of South Carolina, Department of Psychology, College of Arts and Sciences, Columbia, SC.
Research square
|December 9, 2024
概括
食纤维摄入量与灰质大脑体积 (GMV) 有积极的联系,而高热量饮食与减少的GMV相关. 这些发现表明饮食影响大脑健康,并可能为痴呆症预防策略提供信息.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 放射学 放射学是一门学科.
背景情况:
- 阿尔茨海默病和相关的痴呆症给社会和经济带来了巨大的负担.
- 这些情况通常与皮质灰质体积 (GMV) 的减少有关.
- 饮食因素越来越多地被认为对大脑健康和认知功能的潜在作用.
研究的目的:
- 研究食纤维度,食卡路里密度和区域GMV之间的关系.
- 探索不同成年人群中饮食对大脑结构的潜在影响.
- 为了确定与饮食摄入模式相关的特定大脑区域.
主要方法:
- 一项试点横截面研究,涉及190名年龄在20-79岁之间的参与者.
- 利用了2015年国家卫生访谈调查补充和T1加权MRI扫描的数据.
- 使用CAT12基于voxel的形态测量量量化GMV,并通过斯皮尔曼等级相关性分析了与饮食措施的相关性.
主要成果:
- 在包括海马体在内的16个大脑区域中,在食纤维摄入量和GMV之间发现了显著的正相关性.
- 在3个大脑区域,如前中心环和thalamic pulvinar中,在高饮食卡路里密度和GMV之间观察到显著的负相关性.
- 在对年龄和种族进行控制后,这些关联仍然很重要.
结论:
- 食纤维和卡路里密度与区域灰质体积有关.
- 研究结果表明,饮食成分可能在维持大脑结构方面发挥作用.
- 进一步的研究可以为那些面临认知衰退和痴呆症风险的人提供饮食建议.
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