在45岁以上,甲状腺功能正常的中国社区受试者中,探索肌肉质量和甲状腺功能之间的关联:横截面分析
Zaisheng Zhu1,2,3, Yidan Qian1, Pan Ding4
1Department of Medical Care Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Frontiers in endocrinology
|December 9, 2024
概括
在甲状腺功能正常的中年和老年中国人中,较低的自由T3与自由T4比率与肌肉质量减少有关. 这一发现强调了甲状腺激素平衡对于维持骨肌肉指数的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 肌肉生理学 肌肉生理学
背景情况:
- 中年和老年中国人与正常的甲状腺功能之间的肌肉质量和甲状腺激素水平之间的关系还不太清楚.
- 甲状腺激素在新陈代谢和肌肉功能中起着至关重要的作用.
研究的目的:
- 调查中年和老年中国人的肌肉质量和甲状腺功能状态之间的关联,甲状腺功能正常.
- 为了确定甲状腺激素水平与骨肌肉指数 (SMI) 在这个人群中是否相关.
主要方法:
- 一项对1868名中国参与者的回顾性研究 (平均年龄为53.97岁,60.97%是男性).
- 使用生物电阻分析 (BIA) 来计算SMI的身体组成.
- 评估了甲状腺激素水平 (FT3,FT4,TSH),生化指数和慢性疾病.
- 使用斯皮尔曼相关性和二进制物流回归分析来确定关联.
主要成果:
- 在低肌肉质量和FT3/FT4比率 (OR=0.044,P=0.008) 和FT3水平 (OR=0.697,P=0.025) 之间发现了显著的反相关性.
- 没有观察到与TSH或FT4水平有显著的相关性.
- 在对混因素进行调整后,在整个研究人群中确定了SMI和FT3/FT4之间的正相关性.
- 按性别,年龄和体重分层分析显示出一致的相关性趋势.
结论:
- 中年和老年华人的肌肉质量减少,甲状腺功能正常,与FT3/FT4比率较低有关.
- 甲状腺激素平衡,特别是FT3/FT4比率,可能是维持肌肉质量的重要因素.
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