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Updated: Jun 5, 2025

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress
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Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress

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雅塔基米辛生物合成需要两个脱氧核糖核酶来实现毒素自我抵抗

Jonathan Dorival1, Hua Yuan2, Allison S Walker1,3

  • 1Department of Biological Sciences, Vanderbilt University Nashville Tennessee USA brandt.eichman@vanderbilt.edu.

RSC chemical biology
|December 9, 2024
PubMed
概括

雅塔基米辛 (YTM) 耐药性涉及DNA修复. YtkR4和YtkR5酶修复YTM造成的DNA损伤,确保宿主生存和天然产品生物合成. 这些酶也可能提供替代修复途径.

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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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