两个阶段的早产婴儿配方对早产婴儿生长,营养生物标志物和神经发育的影响
Przemko Kwinta1, Svilena Lazarova2, Klaudia Demová3
1Department of Pediatrics, Jagiellonian University, Krakow, Poland.
Frontiers in pediatrics
|December 9, 2024
概括
这项研究表明,一种新的两阶段早产婴儿配方有效地支持生长和神经发育. 这种配方在出生时体重非常低的婴儿中显示出安全的蛋白质和骨生物标志物概况.
科学领域:
- 新生儿营养新生儿营养
- 儿科胃肠病学 儿科胃肠病学
- 婴儿发育 婴儿发育
背景情况:
- 过早出生的婴儿需要特殊的营养来实现最佳的生长和神经发育.
- 富含营养的配方与量身定制的蛋白质水平对于这一群体至关重要.
- 为了满足这些需求,开发了一种新的液体两级配方系统.
研究的目的:
- 评估一种新的两阶段预制配方系统的安全性和有效性.
- 评估配方对生长,营养状况和神经发育的影响.
- 为了确定配方的耐受性和安全性概况.
主要方法:
- 一项前性,开放性研究,涉及非常低出生体重的早产婴儿 (≤1,500克,≤32周怀孕).
- 婴儿接受了第一阶段的配方奶粉,直到1800克,随后接受了第二阶段的退院后 (PD) 配方奶粉30天.
- 主要终点:体重增加速度 (WGV) 与非劣势和优势边缘相比;次要终点包括生长z-score,养耐受性,生物标志物,安全性和2年神经发育 (BSID-III).
主要成果:
- 与既定生长标准相比,双阶段配方实现了明显更高的体重增长速度 (23.0 g/kg/day).
- 营养生物标志物保持在正常范围内,表明蛋白质和矿物质状况充足.
- 在24个月的校正年龄时,婴儿表现出正常的认知发育 (平均BSID认知得分为97.3),没有与配方相关的不良事件.
结论:
- 这种两阶段的早产婴儿配方系统有效地支持产后体重增加和整体生长.
- 配方证明了安全的营养状况,并为早产婴儿的正常认知发育做出了贡献.
- 这种量身定制的营养方法对于出生体重非常低的早产婴儿来说是安全有效的.
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