香白藻 (Candida albicans) 通过逐步生成新的表型来增强金黄色葡萄球菌 (Staphylococcus aureus) 的毒性
Betsy Verónica Arévalo-Jaimes1,2, Eduard Torrents1,2
1Bacterial infections and antimicrobial therapies group, Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac Street 10, 08037, Barcelona, Spain.
Current research in microbial sciences
|December 9, 2024
概括
在Candida albicans的附近,Staphylococcus aureus通过中和pH而形成更有毒的殖民地. 这种真菌相互作用增强了细菌的毒性,影响了宿主病原发生.
科学领域:
- 微生物学 微生物学
- 病原发生和发病.
- 微生物相互作用
背景情况:
- 菌和黄金葡萄球菌经常在与生物膜相关的感染中同时发生,特别是在医疗设备中.
- 这种多微生物的关联对两种物种都有好处,对宿主有害.
- 了解非物理相互作用对于阐明协同毒性至关重要.
研究的目的:
- 为了研究由接近白菌 (Candida albicans) 引起的金黄色葡萄球菌 (Staphylococcus aureus) 殖民地变异.
- 为了确定真菌-细菌非物理相互作用对细菌毒性的影响.
主要方法:
- 近距离测定通过在不同距离 (6距离) 的亚格板上共培养C. albicans和S. aureus殖民地进行了9-10天.
- 在S. aureus殖民地观察到表型变化.
- 用Galleria mellonella幼虫模型来评估S. aureus变种的毒性.
- 进行了基因表达分析 (RNA III和agrA).
主要成果:
- 长时间接近C. albicans诱导S. aureus的殖民地变异,与真菌介导的pH中和有关.
- 这些S. aureus变种在Galleria mellonella模型中表现出与对照组相比的毒性增加.
- 观察到RNA III和agrA表达的升级,这表明阿尔法毒素的作用.
结论:
- 菌可以通过非物理相互作用增强金黄色葡萄球菌的毒性,从而导致更具侵略性的细菌殖民地出现.
- 由真菌引起的环境变化 (例如,pH值变化) 可以显著影响细菌的毒性和病原性.
- 这项研究强调了环境线索,基因调节和多微生物感染中的毒性之间的复杂相互作用.
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