饮食炎症指数得分和认知衰老:来自Framingham心脏研究后代队列的结果
medRxiv : the preprint server for health sciences
|December 9, 2024
概括
饮食炎症指数 (DII) 指出的较高的促炎饮食与语言理解和全球认知的认知下降速度较慢有关. 然而,它们也与处理速度和执行功能的更快下降有关.
科学领域:
- 营养与饮食学 营养与饮食学
- 神经科学是一个神经科学.
- 流行病学 流行病学
背景情况:
- 受饮食影响的慢性炎症与痴呆症的发展有关.
- 饮食炎症指数 (DII) 量化了饮食的炎症潜力.
研究的目的:
- 调查较高的DII分数 (促炎饮食) 与认知衰退之间的关联.
- 在基于社区的队列中,检查与饮食模式相关的时间上的认知变化.
主要方法:
- 分析了来自Offspring Framingham心脏研究 (FHS) 的1,614名老年人.
- 在多个检查周期中,通过食物频率问卷 (FFQ) 收集了饮食数据.
- 累计的DII分数被计算出来,并与认知测试表现相关联,平均随访时间为7年,调整为共变量.
主要成果:
- 较高的DII分数与相似性 (口头理解/推理) 和全球认知 (Global cognition) 的较慢下降有关.
- 较高的DII与Trail Making B-A (处理速度和执行功能) 的加速下降有关.
- 在男性中,较高的DII得分和视觉组织的较慢下降之间观察到线性关系.
结论:
- 这项研究提出了关于促炎性饮食和认知衰退之间的关联的复杂发现.
- 意想不到的结果需要谨慎,特别是考虑到DII得分较高和痴呆风险之间的先前关联.
- 建议通过敏感的神经心理测试进行进一步的纵向研究,以澄清DII与与年龄相关的认知衰退之间的关系.
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