甘油三和高密度胆固醇在正常体重男性中调解腰围和高尿血之间的关联
Wen-Xia Cui1, Shi-Wen Wang1, Lei Gao1
1Department of Geriatrics, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|December 9, 2024
概括
腰围升高 (WC) 会增加正常体重男性的高尿路血症风险. 三糖化物 (TG) 和高密度脂蛋白胆固醇 (HDL-C) 显著调解这种关联,强调监测这些因素的重要性.
科学领域:
- 代谢健康 代谢健康
- 心血管疾病风险因素 心血管疾病风险因素
- 临床内分泌学 临床内分泌学
背景情况:
- 高尿路血症与肥胖和脂质不良症有关.
- 在正常体重的男性中,腰围 (WC) 和高尿血之间的特定关系,考虑到脂质配置文件,仍然不清楚.
研究的目的:
- 调查三甘 (TG) 和高密度脂蛋白胆固醇 (HDL-C) 在正常体重男性中WC和高尿素血的关联中的调解作用.
主要方法:
- 从2021-2023年对35,984名正常体重男性 (BMI18.523.9 kg/m2) 的回顾性观察研究.
- 使用多变量回归模型和调解分析进行分析,以评估WC,血液脂质和高尿血之间的关系.
主要成果:
- 在正常体重的男性中,发现WC和高尿素血症之间存在显著的积极关联 (P < 0.001).
- 超尿血的几率比率在WC四分位数中增加,显著的间接影响由TG (22.3%) 和HDL-C (18.3%) 介导.
结论:
- 升高的WC是正常体重男性高尿血的独立危险因素.
- TG和HDL-C扮演着重要的调解角色,这表明它们在风险评估中的重要性.
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