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皮肤填充剂的自发和诱导降解:一篇综述

Uwe Wollina¹, Alberto Goldman²

¹Department of Dermatology and Allergology, Municipal Hospital Dresden, Dresden, Germany.

Journal of cutaneous and aesthetic surgery

|December 9, 2024

概括

皮肤填充剂的降解因类型而异. 氨酸填充剂自然分解,而半永久填充剂随着时间的推移而降解. 永久填充剂可以保持无限期,激光处理作为去除选项.

科学领域:

审美医学是一种美学医学.
生物材料科学是生物材料的科学.
皮肤病学皮肤病学

背景情况:

皮肤填充剂在美容医学中广泛使用.
有各种临时,半永久和永久填充剂的选择.
了解填充剂降解对于患者安全至关重要.

研究的目的:

审查皮肤填充剂的自发和诱导降解在体外和体内.
分析不同类型填充剂的降解机制.
通过考虑填充剂的可降解性,为安全评估提供信息.

主要方法:

现有文献的叙述性审查.
对氨酸,聚D,L) 乳酸和氧化填充剂的降解途径的分析.
检查影响填充剂持久性和去除方法的因素.

主要成果:

氨酸填充剂通过氨基酶和活性氧物种降解.
半永久性填充剂 (多多-D,L-乳酸,氧化) 通过水解和骨质细胞酶分解,持续长达2-5年.
永久填充剂没有记录的降解,并保持终身;激光治疗是切除手术的替代方案.

结论:

填充剂降解机制根据材料组成有很大的不同.
氨基酶和交叉链接影响氨酸填充剂的寿命.
对填充剂可降解性的评估对于提高美学程序中的患者安全至关重要.

关键词:

含的氧化酸盐.降解降解是一种降解.皮肤填充剂是一种皮肤填充剂.氨酸是什么? 氨酸是什么?聚基化物聚基化物聚基化物聚乳酸是一种多乳酸.聚合甲基烯酸盐是多聚合甲基烯酸盐的一种.

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