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严重阻断性睡眠呼吸暂停的记忆相关区域性脑输液减少,在清醒期间出现轻度认知障碍

Xiangbo Yan^1,2, Wanqing Liu³, Danyang Li¹

¹Imaging Department, Affiliated Zhongshan Hospital Dalian University, Dalian, People's Republic of China.

Nature and science of sleep

|December 9, 2024

概括

阻塞性睡眠呼吸暂停 (OSA) 与认知障碍 (CI) 有关. 在特定的大脑区域,特别是那些涉及记忆的区域,大脑血流减少,随着OSA的严重程度而恶化,解释了CI的发展.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
睡眠医学睡眠医学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 是一种已知的认知障碍 (CI) 风险因素.
在OSA患者中CI背后的精确神经病理机制仍然不完全理解.
脑血 perfusion 变化被假设在 OSA 诱导的 CI 中发挥作用.

研究的目的:

研究阻塞性睡眠呼吸暂停 (OSA) 中认知障碍 (CI) 的神经病理基础.
检查大脑血液输液的改变作为OSA患者CI发展的潜在机制.

主要方法:

招募了35名未经治疗的OSA患者 (15名具有CI,20名没有CI) 和15名良好的睡眠者 (GS).
用于诊断的多睡眠学和西门子3.0特斯拉MRI与脉动动脉旋标签用于休息状态的大脑扫描.
进行了一系列综合的神经心理测试以评估认知功能.

主要成果:

与GS相比,OSA两组 (CI和NCI) 在部和中部前部区域的区域脑血流 (rCBF) 减少.
与NCI组相比,CI组在下和语言回旋中表现出较低的rCBF,在轨道前回旋中表现出较高的rCBF.
在较低的时间和语言转移中的rCBF与CI组的记忆和注意力得分正相关.

结论:

异常的大脑输液,特别是与记忆相关的区域,在有或没有CI的OSA患者中很明显.
观察到血 perfusion 降低的梯度: 睡眠良好> OSA 没有CI> OSA 与CI.
这些发现强调了脑血流减少是与OSA相关的认知障碍发展的关键神经病理因素.

关键词:

阻塞性睡眠呼吸暂停症是什么动脉旋转标签的标记大脑的血液流动.认知障碍是一种认知障碍.记忆的功能记忆的功能记忆的功能

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