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ST8-t008-SCC IV抗甲基黄金葡萄球菌在零售新鲜奶酪中的耐药性

Carolina Chaves^1,2, Melissa Montenegro¹, Hyrina Piedra¹

¹Facultad de Microbiología, Universidad de Costa Rica, San Pedro de Montes de Oca, 11501-2060 San José, Costa Rica.

JDS communications

|December 9, 2024

概括

在哥斯达黎加奶酪中发现了三种多抗药性甲素耐药黄金葡萄球菌 (MRSA) 菌株. 这些ST8-t008-SCC IVa (2B) 菌株携带耐药性和毒性基因,构成食品安全风险.

科学领域:

微生物学微生物学
食品安全食品安全
基因组学就是基因组学.

背景情况:

甲素耐药黄金葡萄球菌 (MRSA) 是一个重要的公共卫生问题.
食品传播的MRSA存在多种耐药性感染的风险.
之前的研究已经在各种食品中发现了MRSA.

研究的目的:

来自哥斯达黎加的新鲜奶酪中识别和描述MRSA菌株.
为了确定检测到的MRSA菌株的抗微生物耐药性和毒性因素.
评估MRSA在食品供应中的潜在公共卫生影响.

主要方法:

从新鲜奶酪样本中分离和识别MRSA.
基因组分析以检测耐药性和毒性基因.
对抗微生物素敏感性的表型测试.

主要成果:

确定了三种ST8-t008-SCC IVa (2B) MRSA菌株,其中包括三种ST8-t008-SCC.
这些菌株对β-乳糖胺和红红素有抗性,携带mca,blaZ,mph (C) 和msr (A) 基因.
获得的耐药性基因 (aph(3') -III, fosD) 和毒性因子 (粘附素,血清素,外毒素) 都存在.
基因组特征与恶毒的USA300 MRSA血统相似.

结论:

哥斯达黎加的新鲜奶酪可以携带多抗药性ST8MRSA.
这些发现表明,奶酪生产中存在潜在的安全缺陷.
难以治疗的MRSA菌株的食物传播构成了严重的公共卫生风险.

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