在口腔癌前病变和状细胞癌症中的细胞食人主义
Zohreh Jaafari-Ashkavandi1,2, Azadeh Andisheh Tadbir2, Asa Rahmatabadi2,3
1Biomaterial Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Iranian journal of otorhinolaryngology
|December 9, 2024
概括
细胞性食人主义,一种非亡性细胞死亡,存在于口腔癌和发育不良症中. 这一发现表明它可能表明恶性转变和高度口腔病变.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 病理学 病理学 病理学
背景情况:
- 细胞食人是一种与癌症攻击性相关的非亡性细胞死亡过程.
- 这种现象与恶性瘤的侵入性和转移潜力有关.
研究的目的:
- 评估细胞食肉在口腔失塑性病变和口腔状细胞癌 (SCC) 的存在和意义.
主要方法:
- 一项横截面研究分析了31例口腔SCC,30例上皮质发育不良和36例皮炎 (HK) 病例.
- 在10个高功率场中检查了血素和氨酸染色组织部分的细胞食人行为.
- 统计分析包括克鲁斯卡尔-瓦利斯和费舍尔的精确测试.
主要成果:
- 在所有SCC病例中检测到细胞食人行为,58.3%的发育不良病变和3.7%的HK病例.
- 与HK (0.03±0.18) (P<0.001) 相比,SCC (19.48±4.94) 和发育不良 (1.03±1.25) 的平均食人数显著更高.
- 较高程度的发育不良和癌症显示了食人细胞的增加.
结论:
- 细胞食人现象存在于口腔状细胞癌和口腔表皮质质变形,在SCC中流行率明显更高.
- 这种现象与分化度相关,可以作为恶性转变和高度口腔病变的标准.
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