细颗粒物和卵巢健康:对新兴风险的审查
Qingqing Tao1, Zhengyang Zhao1, Rui Yang2,3,4
1Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China.
Heliyon
|December 9, 2024
概括
细颗粒物 (PM2.5) 暴露与卵巢障碍有关,如卵巢储备减少,PCOS和不孕症. 本综述详细介绍了PM2.5影响卵巢功能的机制,包括氧化应激和炎症.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
背景情况:
- 细颗粒物 (PM2.5) 污染对公众健康构成风险,特别是对弱势群体.
- 现有的研究表明,PM2.5暴露与卵巢功能障碍之间存在联系.
- 将PM2.5与卵巢疾病联系在一起的精确生物机制仍然不完全理解.
研究的目的:
- 审查和阐明与PM2.5暴露相关的主要卵巢疾病.
- 详细介绍PM2.5对卵巢功能的特定病理生理影响.
- 巩固目前对PM2.5对生殖健康的影响的理解.
主要方法:
- 文献综述综合了关于PM2.5和卵巢健康的研究.
- 对调查PM2.5.5的分子和细胞影响的研究进行分析.
- 识别和讨论受PM2.5.5影响的关键生物通路.
主要成果:
- 暴露于PM2.5与卵巢储备减少,多囊性卵巢综合征 (PCOS) 和不孕症有关.
- 关键机制包括增加反应性氧物种 (ROS) 生产,亡,DNA损伤和炎症.
- 这些影响会破坏正常的卵巢生理和功能.
结论:
- 通过多种有害途径,PM2.5暴露对卵巢健康构成重大威胁.
- 了解这些机制对于制定预防策略和降低风险至关重要.
- 需要进一步的研究,以充分解决空气污染对生殖健康的影响.
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