甲基化物ER多单元颗粒系统在ADHD患者的安全性和有效性:一项开放标签研究
Renata Schoeman1, Evelyn Y Lai2, Anne-Marie Nel3
1Stellenbosch Business School, Stellenbosch University, Stellenbosch, South Africa.
概括
康特拉米尔XR在南非的一项现实研究中有效管理了注意力缺陷过敏障碍 (ADHD) 症状. 患者表示满意和愿意继续这种延长释放甲基胺治疗.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 注意缺陷多动障碍 (ADHD) 是一种影响儿童和成人的神经发育障碍.
- 药物治疗,特别是甲基,是ADHD的主要治疗方法.
- 治疗ADHD药物的传递机制可能会影响患者的结果.
研究的目的:
- 评估多个单元颗粒系统在ADHD患者中提供的延长释放甲基化物 (Contramyl XR) 的现实有效性.
- 评估用Contramyl XR的症状控制和患者报告的结果.
- 为了比较Contramyl XR与标准的甲基化物治疗.
主要方法:
- 在南非进行的第四阶段,开放标签,前性,观察性研究.
- 纳入了119名成人和儿童多动症参与者 (治疗前和转换).
- 使用威斯功能障碍评级尺度 (WFIRS) 在12周内测量有效性.
主要成果:
- 在4周和12周的WFIRS分数显著改善 (p < 0.001).
- 之前没有接受过治疗的患者报告说,他们对Contramyl XR的满意度很高.
- 切换患者的疗效与他们之前的甲基胺治疗相比,效果相似.
结论:
- 康特拉米尔XR在临床上是有效的,作为ADHD的初始治疗和切换选择.
- 药物耐受性很好,所有参与者都选择继续治疗.
- 康特拉米尔XR为ADHD管理提供了一种可行的替代甲基化物输送系统.
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