克洛沙/诺克洛沙血水平比率和精神分裂症谱系障碍患者的认知功能:系统性审查
Timo T Moscou1, Selene R T Veerman2,3
1Department of Community Mental Health, Mental Health Service Noord-Holland Noord, Alkmaar, Oude Hoeverweg 10, Noord Holland 1816 BT, The Netherlands.
Therapeutic advances in psychopharmacology
|December 9, 2024
概括
在精神分裂症中克洛扎/诺克洛扎比率和认知功能的研究是有限的. 目前的证据不支持诺克洛沙平的前认知作用,使得个性化克洛沙平治疗成为遥远的可能性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 认知障碍在精神分裂症谱系障碍 (SSD) 中显著影响生活质量.
- 治疗耐药精神分裂症 (TRS) 对认知功能的研究有限且质量低.
- 克洛扎 (CLO) 用于TRS,但其对认知的影响是不一致的;其代谢物诺克洛扎 (NCLO) 可能具有预认知效应.
研究的目的:
- 系统地审查有关CLO/NCLO比率与SSD患者认知功能之间的联系的现有文献.
主要方法:
- 我们对Embase,PsycINFO,PubMed和Cochrane数据库进行了全面的搜索.
- 包括15项研究 (4项纵向,11项横截面),涉及953名成年克洛扎使用者,治疗耐药性各不相同.
- 11项研究被评为相当优质,设计异质,混因素分析有限.
主要成果:
- 一项纵向研究表明,CLO/NCLO比率与注意力/警觉性以及社会认知之间存在负面关系.
- 在CLO/NCLO比率和处理速度,推理,解决问题,工作记忆或口头/视觉学习之间没有发现显著的相关性.
- 研究设计和人群的异质性,以及对混因素的不一致分析,限制了最终的结论.
结论:
- 目前的临床证据不足以支持诺克洛zapine (NCLO) 有预认知效应的假设.
- 通过调节CLO/NCLO比率来进行个性化克洛扎宾 (CLO) 治疗目前是不可能的.
- 需要进一步的研究,承认现有研究的局限性,并探索潜在的混因素.
相关概念视频
01:26Psychosis: Goals of Pharmacotherapy
103
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
103
01:28Psychosis and Antipsychotic Drugs: Overview
176
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
176
01:30Negative and Cognitive Symptoms of Schizophrenia
43
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
43
01:28Drug Therapy
39
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
39
01:21Antipsychotic Drugs: Typical and Atypical Agents
156
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
156
01:29Psychological and Sociocultural Causes of Schizophrenia
71
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
71