在全膝关节整形术中重新定义术后疼痛管理中的鼻内塔的实用性:一项前性观察性研究
Prashant Kamble1, Sameer Panchal2, Rudra M Prabhu1
1Orthopaedics, Seth Gordhandas Sunderdas (GS) Medical College and King Edward Memorial (KEM) Hospital, Mumbai, IND.
Cureus
|December 9, 2024
概括
塔潘塔多尔鼻喷剂有效地控制了全膝关节整形术的疼痛. 这种由患者控制的止痛疗法提供了快速,持久的缓解,副作用最小,改善了患者的舒适度和手术后的结果.
科学领域:
- 整形外科 整形外科 整形外科
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 有效的术后疼痛管理对于在全膝关节整形术 (TKA) 后的功能恢复至关重要.
- 与静脉注射或口服途径相比,鼻腔内注射的塔达尔提供了快速吸收和优异的疼痛缓解.
- 优势包括提高患者的舒适性,方便性和安全性.
研究的目的:
- 为了评估TAPENTADOL鼻喷雾作为患者控制的止痛药 (PCA) 治疗术后疼痛的有效性和安全性.
- 评估TKA后的疼痛减轻,作用开始和镇痛的持续时间.
主要方法:
- 一个单中心前性观察性研究包括120名接受单边TKA的患者.
- 塔潘塔多尔鼻喷雾剂 (22.5 mg/喷雾剂) 进行了术后的使用.
- 在术后1-3天使用视觉模拟量表 (VAS) 评估疼痛,记录治疗前和后的分数,轻度疼痛的时间和疼痛恶化的时间.
主要成果:
- 在PODs1-3 (p<0.001) 中,平均VAS得分从喷前 (8.07,7.64,7.40) 到喷后 (4.63,4.71,3.95) 显著下降.
- 达到轻度疼痛的时间从POD1显著减少到POD3 (p<0.001).
- 疼痛从轻度到中度/重度恶化的时间从POD 1到POD 3显著增加 (p<0.001),没有重大不良事件.
结论:
- 鼻内塔多尔喷雾剂是TKA患者术后疼痛管理的有效和安全选择.
- 它提供了快速发作,持久的止痛,可以自给自取,副作用最小.
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