一些炎症参数可以预测患有恶性多叶流液的患者的存活率吗?
Nur Dilvin Ozkan1, Aynur Bas2, Axel Scheed3
1Department of Thoracic Surgery, Milas State Hospital, Muğla, Türkiye.
Turk gogus kalp damar cerrahisi dergisi
|December 9, 2024
概括
血清炎症标记物,如C-反应蛋白 (CRP) 和中性粒细胞与淋巴细胞比率 (NLR) 可以帮助预测恶性流 (MPE) 患者的生存率. 这些简单的标记器提供了一个具有成本效益的预后工具.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 炎症研究 炎症研究
背景情况:
- 恶性流 (MPE) 在患者管理中构成了重大挑战.
- 确定可靠的预后标志物对于优化治疗策略至关重要.
研究的目的:
- 调查血清炎症标志物与被诊断为MPE的患者的存活率之间的相关性.
- 确定MPE中特定炎症标志物的预后值.
主要方法:
- 这是一项前性研究,涉及125名接受胸腔切除的MPE患者.
- 整体生存分析和接收器运行特征 (ROC) 分析,以确定与死亡率相关的炎症参数的切断值.
- 评估东部合作性瘤组 (ECOG) 的得分,C反应蛋白 (CRP),中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),流体白蛋白和乳酸脱酶 (LDH) 的比率.
主要成果:
- 对于MPE患者,中位生存期为6个月,三年和五年生存率分别为16%和4%.
- 在存活率和ECOG得分,CRP,NLR,PLR以及血清LDH与多发性LDH的比率之间发现了显著的相关性.
- 较高的CRP,NLR,PLR和血清LDH-to-pleuralLDH比率被确定为统计学上显著的不良预后因素.
结论:
- 血清炎症标志物,包括高CRP,NLR,PLR和血清LDH-to-pleuralLDH比率,作为MPE患者预后的简单和成本有效的预测剂.
- 这些标记可以帮助临床医生评估患者的前景,并指导治疗决策.
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