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奎尔塞丁和阿斯特拉加洛西德IV可缓解孕期暴露于氧化纳米颗粒所引起的发育异常

Li Ji¹, Qiuru Huang¹, Yujuan Qi²

¹Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong 226001, China.

|December 9, 2024

概括

孕期接触氧化 (ZnO) 纳米颗粒会导致发育问题. 奎尔塞丁和阿斯特拉加索酸IV补充剂通过向铁亡途径有效地减轻了这些影响.

科学领域:

纳米技术纳米技术
发育毒理学发展毒理学
药理学药理学是指药理学的学科.

背景情况:

氧化纳米颗粒 (ZnO NPs) 被广泛使用,引发了对潜在细胞毒性的担忧.
对于ZnO NP的妊娠性毒性,监管格局和干预策略尚未明确.

研究的目的:

为了研究ZnO NPs.的孕期毒性.
评估奎尔丁和阿斯特拉加索酸IV对ZnO NP诱导的发育毒性的保护作用.
阐明潜在的机制,特别是铁灭的作用.

主要方法:

使用 *Drosophila* 模型进行 *in vivo* 研究.
怀孕期间服用ZnONP和评估发育结果.
补充饮食与奎尔丁和阿斯特拉加洛oside IV.
研究了铁灭菌路径及其调节.

主要成果:

孕期暴露于ZnONP引起了剂量依赖的生长和发育异常.
奎尔塞丁和阿斯特拉加索酸IV的使用有效地减轻了ZnO NP诱导的发育毒性.
ZnO NPs引发了铁亡,而Quercetin,Astragaloside IV和Ferrostatin-1可以改善这种情况.

结论:

孕期暴露于ZnONP会通过ferroptosis途径损害生长和发育.
饮食中的奎尔丁和阿斯特拉加索酸IV可对ZnO NP发育性毒性提供显著的保护.
向铁亡是一种潜在的治疗策略,可以减轻ZnO NP诱导的发育损害.

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