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Updated: May 28, 2026

Isolating Potentiated Hsp104 Variants Using Yeast Proteinopathy Models
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与ALS相关的辅助器DNAJC7通过调节HSF1活动来调节神经保护,防止蛋白质毒性压力

Andrew C Fleming, Nalini R Rao, Matthew Wright

    bioRxiv : the preprint server for biology
    |December 9, 2024
    PubMed
    概括

    在DNAJC7中发生的突变,热冲击蛋白的辅导体,导致罕见的ALS. DNAJC7损失会影响运动神经元应激反应和RNA处理,这表明HSF1是ALS的治疗点.

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