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Updated: Jun 5, 2025

Design and Use of a Low Cost, Automated Morbidostat for Adaptive Evolution of Bacteria Under Antibiotic Drug Selection
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Design and Use of a Low Cost, Automated Morbidostat for Adaptive Evolution of Bacteria Under Antibiotic Drug Selection

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一种用于优化抗生素的生成人工智能方法

Marcelo D T Torres, Yimeng Zeng, Fangping Wan

    bioRxiv : the preprint server for biology
    |December 9, 2024
    PubMed
    概括

    一个新的人工智能 (AI) 框架APEX生成优化 (APEX GO) 设计了新型抗菌来对抗抗菌素耐药性 (AMR). 这种人工智能方法加速了基于的有效抗生素的发现.

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    Antibiotic Selection

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    Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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    The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
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    In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
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