CalliCog:一个开源的认知神经科学工具包,用于自由行为非人类灵长类动物
bioRxiv : the preprint server for biology
|December 9, 2024
概括
我们开发了CalliCog,这是一个用于非人类灵长类动物 (NHP) 认知研究的自动化子系统. 这种开源平台成功地训练了松鼠完成复杂的任务,并集成了神经记录,使NHP认知研究更容易获得.
科学领域:
- 认知神经科学 认知神经科学
- 灵长类动物研究研究
- 神经科学 技术 技术 神经科学
背景情况:
- 非人类灵长类动物 (NHP) 的认知研究通常仅限于专门的实验室.
- 像海这样的小型NHP是有价值的模型,但研究是劳动密集型和专家依赖的.
- 现有的方法对更广泛的科学界参与构成可访问性障碍.
研究的目的:
- 介绍CalliCog,一个开源的,用于小型NHP的自动认知实验的子平台.
- 为了实现自由行为实验,将行为分析与神经记录结合起来.
- 减少与NHP认知研究相关的技术障碍和成本.
主要方法:
- 开发了模块化,自主操作室,可以与小型NHP的家用子集成.
- 使用CalliCog进行基于触摸屏的认知任务训练,用于普通海 (Callithrix jacchus).
- 同步的行为数据与自由移动的动物的电皮质谱 (ECoG) 记录.
主要成果:
- 在两个设施中,在两周内,经过实验的天真海在两周内获得了触摸屏的熟练程度.
- 松鼠成功完成了评估行为灵活性和工作记忆的任务.
- 实现了行为和神经数据的精确同步,使先进的神经行为研究成为可能.
结论:
- 通过提供一个可访问的,自动化的平台,CalliCog使小NHP的认知实验民主化.
- 该系统有效地训练海,并与神经记录集成,推进认知神经科学.
- CalliCog的开源可访问性旨在缩小临床前模型和人类认知之间的翻译差距.
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