从CERTITUDE注册表中,与心室节律失常相关的设备衍生的日常活动的时间变化
Valentina Kutyifa1, Michael Christof1, Steven Mullane2
1Division of Cardiology, Department of Medicine, University of Rochester, Rochester, New York.
Heart rhythm O2
|December 9, 2024
概括
在用休克治疗心室节律失常 (VAs) 后,设备测量的日常活动下降,但在此之前没有. 这项研究分析了超过5600名患者,发现VA后的活动下降,而不是在他们之前.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 数据科学数据科学数据科学
背景情况:
- 关于植入器件的日常活动与心室节律失常 (VAs) 之间的时间联系的数据有限.
- 了解这种关系对于管理心脏病和器械治疗至关重要.
研究的目的:
- 调查日常活动是否预测VA或VA是否预测活动的后续变化.
- 分析围绕VA事件的设备衍生活动的时间模式.
主要方法:
- 分析了来自CERTITUDE注册表的5600多名患者,其中包括植入设备和家庭监控.
- 利用1轴加速度计数据来跟踪日常活动.
- 与VA事件相比,在7天窗口 (基线,事件前,事件后) 中检查的活动变化,按心率和治疗 (冲击/节奏) 分类.
- 采用二项式比例测试和案例交叉分析.
主要成果:
- 在VA事件>200次/分钟以后,观察到活动显著下降,并用休克治疗 (中位数减少8.7%).
- 用冲击治疗的VA事件 ≤200次/分钟也显示了事件后的活动减少 (中位数 -5.8%).
- 在VA事件>200次/分钟之前或在接受抗心动鼓动治疗之前/之后,没有发现活动显著减少.
结论:
- 在心室失常事件发生后,设备衍生的日常活动暂时下降,特别是那些经过冲击治疗的>200次/分钟.
- 在VA事件 ≤200节拍/分钟后观察到活动减少,用冲击治疗.
- 没有证据表明日常活动的变化会在VA的冲击事件之前发生.
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