氨基酸对甲状腺素诱导的老化小鼠认知能力改善的影响
Chong Yuan1,2, Hongtao Ren1,2, Kexin Hu1,2
1Zhengzhou Key Laboratory of Nutrition and Health Food, College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, China. yuqiuyingzf@163.com.
Food & function
|December 9, 2024
概括
补充普朗托西亚尼丁 (Pc) 通过减少神经炎症和增强免疫反应,改善了老年小鼠的认知功能. 这种饮食方法为打击与年龄相关的认知衰退提供了一个有希望的策略.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 营养科学 营养科学
背景情况:
- 人口老龄化面临着认知障碍和与年龄有关的疾病的风险增加.
- 功能性食补充剂正在探索减轻这些与年龄相关的疾病.
- 认知能力下降是一个重大问题,需要有效的干预措施.
研究的目的:
- 为了评估proanthocyanidins (Pc) 对甲状腺素 (Th) 诱导的老化小鼠模型认知障碍的影响.
- 研究PC对老鼠的神经炎症,免疫水平和认知能力的影响.
主要方法:
- 在小鼠中建立了甲状腺素 (Th) 诱导的衰老模型.
- 给药的普兰托西亚尼丁 (Pc) 和评估认知表现,神经炎症标志物和免疫细胞概况.
- 分析了氧化应激,炎症和神经递质活性的生化标志物.
主要成果:
- 通过降低乙胆酶 (AchE) 活性,Pc显著改善了学习缺陷和空间记忆.
- Pc保持了氧化还原平衡,增加了总抗氧化能力 (T-AOC),谷氨酸 (GSH) 和超氧化脱酶 (SOD),同时降低了髓氧化酶 (MPO) 和甲 (MDA).
- 通过降低质纤维酸蛋白 (GFAP) 和结合适配分子1 (IBA-1) 在海马体中的下调,PC降低了神经炎症,通过调节细胞因子水平,改善了全身炎症.
- 通过增加白细胞 (WBC) 计数和促进平衡的淋巴细胞亚群形状 (CD3 +,CD4 + / CD8 + 比率),PC增强了免疫能力.
结论:
- 普朗索亚尼丁 (Pc) 有效地缓解老年小鼠的认知障碍.
- Pc显示出作为一种功能性食补充剂的潜力,用于支持老年人的认知健康和免疫功能.
- 这项研究提供了一种营养策略,以改善老龄人口的健康.
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