我认为P.P. 感染的巨细胞外细胞囊引起不良妊娠结果
A Tanai1, Y Fukuhara1, T Eguchi2
1Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Journal of dental research
|December 9, 2024
概括
由口腔细菌引起的孕产妇牙周炎可能会损害胎儿的发育. 感染细胞的细胞外囊泡进入胎盘,损害胎儿的生长和胎盘血管的形成.
科学领域:
- 口腔微生物学和免疫学
- 生殖生物学和发育毒理学.
- 细胞和分子生物学是细胞和分子生物学.
背景情况:
- 牙周炎是一种与全身疾病相关的慢性炎症性疾病.
- 孕妇牙周炎与不良妊娠结果有关,但机制尚不清楚.
- 细胞外囊泡 (EVs) 调解细胞间的通信,并与疾病有关.
研究的目的:
- 为了调查EVs是否来自P. 牙感染的巨细胞 (Pg-inf EVs) 影响胎儿-胎盘单元和胎儿发育.
- 阐明Pg-inf EVs对怀孕的影响的分子机制.
主要方法:
- 在体内小鼠模型追踪Pg-inf EV转位和对胎儿发育的影响.
- 胎盘血管和血管生成的组织学分析.
- 对胎盘组织的蛋白质组分析和对人类血管内皮细胞的体外研究.
主要成果:
- Pg-inf EVs 到达胎儿胎盘单元,导致胎儿生长 (大小和体重) 受到损害.
- 胎盘显示血管对齐受损并降低了血管生成.
- Pg-inf EVs在胎盘组织和内皮细胞中降低了Vegfr1的表达,这表明它在血管生成受损中发挥了作用.
结论:
- 这项研究揭示了一条新的途径,即牙周炎影响的巨细胞的EVs会影响怀孕.
- Pg-inf EVs通过降低VEGFR1.1的调节来破坏胎盘功能和胎儿发育.
- 这些发现突出了母亲口腔健康和胎儿健康之间的潜在联系,通过EV介导的沟通.
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