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瘤透淋巴细胞在不同的犬类软组织肉瘤组织学类型中有所不同

Giancarlo Avallone¹, Elena Brigandì¹, Chiara Tugnoli¹

¹University of Bologna, Bologna, Italy.

Veterinary pathology

|December 9, 2024

概括

狗软组织瘤 (STSs) 显示出不同的免疫反应. 周周血管壁瘤 (PWTs) 和myxosarcomas表现出更高的瘤透淋巴细胞 (TILs),表明差异性免疫性和免疫治疗的潜力.

科学领域:

兽医瘤学兽医瘤学
免疫学免疫学免疫学
癌症研究癌症研究

背景情况:

软组织肉瘤 (STSs) 通常被认为是免疫性较差的.
有限的数据存在于免疫细胞透到犬类STS中,缺乏瘤类型分层.
了解犬类STS的免疫反应对于探索免疫治疗潜力至关重要.

研究的目的:

追溯评估瘤透淋巴细胞 (TILs) 在五种不同类型的犬类STSs.
为了比较各种犬类STS类型的免疫细胞密度和比率.
为了研究TILs,瘤等级和STS行为之间的关联.

主要方法:

分析了87种狗类的STS (22种PWT,19种脂类沙瘤,17种纤维沙瘤,16种菌类沙瘤,13种细菌沙瘤).
瘤被分类和免疫标记为CD3 (T细胞),CD20 (B细胞) 和FoxP3 (Tregs).
使用QuPath软件量化TIL密度;计算B/T细胞比率和Treg/T细胞比率.

主要成果:

在周血管壁瘤 (PWTs) 和myxosarcomas中观察到较高的TIL总密度.
PWT显示T细胞密度较高但Treg比例较低,而myxosarcomas则有更高的Treg密度和B/T细胞比率.
在myxosarcomas中,更高的等级与增加的总TIL,CD20+和FoxP3+细胞相关;对于STS总体而言,没有发现等级关联.

结论:

周血管壁瘤 (PWTs) 和myxosarcomas似乎是最具免疫性的狗STS类型.
菌索瘤表现出富含B细胞和Treg的免疫反应,可能与攻击性行为有关.
PWT表现出富含T细胞,Treg-poor反应,可能与更惰的临床过程有关.

关键词:

狗类犬类动物狗类犬类图像分析图像分析软组织肉瘤软组织肉瘤瘤微环境是一个微环境.透到瘤中的淋巴细胞

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