了解多发性硬化症患者客观评估认知和自我报告的心理症状的复杂网络
Maureen van Dam1,2, Jantine G Röttgering3,4, Ilse M Nauta5
1MS Center Amsterdam, Department of Anatomy & Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.
Multiple sclerosis (Houndmills, Basingstoke, England)
|December 9, 2024
概括
在患有多发性硬化症的人群中,患者报告的结果和认知测试往往不同. 网络分析显示,信息处理速度受损与较低的症状相互关系有关,这表明认知状态影响了这种差异.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 康复医学 康复医学 康复医学
背景情况:
- 在科学文献中,自我报告的认知投诉 (SCC) 和客观认知表现之间存在差异.
- 了解这一差距对于管理影响认知的条件至关重要.
研究的目的:
- 研究患者报告的结果指标 (PROM) 与多发性硬化症患者 (PwMS) 的客观认知功能之间的关系.
- 利用网络分析来探索主观和客观认知评估之间的相互作用.
主要方法:
- 收集了703个PwMS的PROM (焦虑,抑郁,疲劳,SCC) 和认知数据.
- 使用高斯图形模型构建认知症状网络.
- 在相关子组中比较全球网络强度,包括那些信息处理速度 (IPS) 减弱与保存的子组.
主要成果:
- 认知症状网络显示了PROM和认知领域的独特模块,它们之间的联系有限.
- 与保持IPS的人相比,受损IPS的PwMS表现出较低的全球网络强度 (表明症状相互关联程度较低) (3.57对4.51,p=0.001).
- 在基于SCC (p=0.140) 的子组进行比较时,没有发现全球网络强度的显著差异.
结论:
- 认知症状网络增强了对自我报告和客观测量的认知功能之间的断开的理解.
- 在PwMS和受损的IPS中症状相互关系的减少表明PROM和认知领域之间存在认知状态依赖的非线性关系.
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