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用于预防辐射诱导的口腔粘膜炎的可纳:一项随机对照试验

Waranyu Ueangphairot¹, Pooriwat Muangwong¹, Phimchat Suwannaphong²

¹Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

|December 9, 2024

概括

在接受化疗放射治疗的头癌患者中,可纳预防显著降低了严重的口腔粘膜炎和Candida携带. 这一发现支持可纳作为一种有效的预防性治疗.

科学领域:

在瘤学瘤学.
传染性疾病传染性疾病
药理学药理学是指药理学的学科.

背景情况:

同时接受化疗放射治疗 (CCRT) 的头癌 (HNC) 患者面临辐射诱导口腔粘膜炎 (RIOM) 的高风险.
菌殖民是CCRT期间常见的并发症,可能会加剧RIOM.
预防策略对于减轻与治疗相关的毒性至关重要.

研究的目的:

评估可纳在预防 RIOM 的疗效.
评估可纳对Candida携带和殖民性的影响.
确定可纳作为预防剂在接受CCRT的HNC患者中的作用.

主要方法:

这是一项前性,双盲,随机对照试验,涉及78名HNC患者.
在CCRT期间,患者每天接受100毫克的可纳或安慰剂.
主要结局:等级≥2 RIOM的发生率. 二次结果:Candida携带者和殖民地形成单位 (CFU).

主要成果:

可纳在第7周显著降低了≥2级RIOM的发生率 (p=0.039).
在第4周和第7周观察到阳性Candida携带的显著减少 (p=0.024,p=0.029).
在第7周,可纳组中,Candida CFU的中位数显著较低 (p=0.050).

结论:

可纳预防药物有效降低HNC患者RIOM的严重程度.
预防性可纳显著降低了在CCRT期间的Candida殖民.
这些发现支持使用可纳作为预防性治疗,以改善HNC患者的治疗结果.

关键词:

这是一种Candida Candida.化学疗法化疗化疗弗卢科纳尔 (Fluconazole) 是一种头部和部癌症头部和部癌症口腔粘膜炎是一种口腔粘膜炎.辐射疗法辐射疗法

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