治疗相关的手脚综合征:一篇综述
Bilha Baby1, Nevin Sam1, Narmadha M P1
1Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, India.
Journal of chemotherapy (Florence, Italy)
|December 9, 2024
概括
手脚综合征 (HFS) 是一种由5FU和多克索鲁比辛等抗瘤药物引起的不良药物反应. 通过干预或剂量调整来管理HFS对于患者的治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 手脚综合征 (HFS) 是一种与各种抗瘤化疗相关的显著不良药物反应.
- HFS的发病因子是多因素的,涉及特定的药物机制,组织病理变化和患者特定的因素.
- 虽然HFS通常不会危及生命,但可以显著损害患者的生活质量和治疗坚持.
研究的目的:
- 阐明化学疗法诱导的HFS背后的多种致病机制.
- 突出HFS的临床表现和影响因素 (如性别,种族,遗传学).
- 强调管理HFS的重要性,以改善患者的治疗结果.
主要方法:
- 对化学疗法诱导的手脚综合征现有文献的综述.
- 分析导致HFS的常见抗瘤药物的致病机制 (例如,5FU,多克索鲁比辛,卡佩西塔,高剂量细胞氨酸).
- 考虑影响HFS发展的组织病理学和临床因素.
主要成果:
- 化学疗法药物如5FU,多克索鲁比辛,卡佩西塔宾和高剂量细胞氨基酸通过不同的致病途径诱导HFS.
- HFS的表现和严重程度可能会受到患者人口统计学,遗传倾向和组织病理学发现的影响.
- 有效的管理策略,包括治疗干预和药物调整,至关重要.
结论:
- 了解HFS的各种机制是有效管理的关键.
- 考虑到患者因素的个性化方法可以优化HFS治疗.
- 对药理和非药理疗法的持续研究对于症状管理和改善患者治疗结果至关重要.
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