自然醇的选择性脂化诱导In Situ 化基天然深度修养溶剂
Sonia Bonacci1, Erika Cione2,3, Mario Coscarella1
1AGreen Food Laboratory Health Sciences Department, Magna Græcia University, Germaneto, CZ 88100, Italy.
Journal of agricultural and food chemistry
|December 9, 2024
概括
这项研究介绍了一种绿色方法,利用天然的深溶性溶剂从醇中制造脂肪酸. 这些新型化合物显示出用于化品和药理学应用的潜力,具有评估的抗氧化活性和低毒性.
科学领域:
- 绿色化学是一种绿色化学.
- 生物化学 生化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 额外处女橄油 (EVOO) 中的醇 (PA) 具有生物活性特性.
- 脂化可以提高PA的生物可用性和应用.
- 天然深层环氧溶剂 (NADES) 提供了一个可持续的反应介质.
研究的目的:
- 开发一种新的,绿色的,具有成本效益的方法,用于从EVOO中选择性脂化关键的醇 (tyrosol,hydroxytyrosol,homovanillyl alcohol).
- 使用NADES合成这些PA的脂肪酸.
- 评估产生的PA脂肪酸的抗氧化酶活性和细胞毒性.
主要方法:
- 醇被用作与胆化物 (ChCl) 的键供体,以形成NADES.
- 用脂肪酸对PA的化是在基于ChCl的NADES中*in situ*实现的,避免使用有机溶剂和催化剂.
- 在H2O2处理的HaCat人体角质细胞中评估了PA-油酸盐配方的抗氧化酶活性 (超氧化物脱酶,谷氨S转移酶) 和细胞毒性 (MTT检测).
主要成果:
- 成功建立了一种快速,廉价和无溶剂的方法来选择性脂化PA.
- 使用NADES合成了新的PA脂肪酸.
- 在细胞模型中,PA-酸盐配方证明了抗氧化酶调节和低毒性.
结论:
- 开发的基于NADES的方法为生产脂友性PA衍生物提供了一个高效和可持续的途径.
- 由于其生物活性和安全性,这些脂友性PA衍生物在化品和制药行业的应用是有前途的.
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