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在住院的婴儿中过度服用抗生素,患有腺病毒感染
Rula Azzam1, Oded Scheuerman1,2, Tal Eidlitz-Markus1,3
1Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Minerva pediatrics
|December 9, 2024
概括
患有腺病毒感染的住院婴儿中有一半接受了不必要的抗生素. 这项研究强调了需要快速进行腺病毒PCR测试,以减少儿童不合理使用抗生素的必要性.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
背景情况:
- 儿童的腺病毒感染可以模仿细菌感染,出现长期发烧和炎症标志物升高.
- 这种临床相似性往往导致实证抗生素的管理.
- 在这些情况下使用抗生素的理由需要仔细评估.
研究的目的:
- 为了确定在被诊断患有腺病毒感染的住院婴儿中使用抗生素的速度.
- 评估处方抗生素治疗的医疗理由.
- 在这个儿科群体中确定与抗生素使用相关的因素.
主要方法:
- 对2个月至2岁的住院患者进行了回顾性分析,通过PCR检测出腺病毒 (Ct <36).
- 收集了临床和流行病学数据.
- 一个由儿科医生组成的小组回顾性地审查了病例,以确定抗生素治疗的合理性.
主要成果:
- 在183名患有腺病毒的儿童中,有92人 (50.3%) 接受了抗生素治疗.
- 只有42.4%的抗生素处方被认为在医学上是合理的.
- 与未接受治疗的儿童相比,接受抗生素治疗的儿童表现出更高的发烧,更高的血氧和和炎症标志物的增加.
结论:
- 大约50%的住院儿科腺病毒病例接受了抗生素治疗,其中大多数被发现是不合理的.
- 常规和快速的腺病毒PCR测试可以显著减少住院儿童不必要的抗生素处方.
- 这种方法可以通过确保适当的治疗选择来帮助打击抗生素耐药性.
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