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Updated: Jun 5, 2025

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通过临床成像和多态学,将虹膜的Cis调节变异与初级角闭眼镜联系起来

Jiaying Li1, Yun Chen2, Wenbin Wang3

  • 1Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Investigative ophthalmology & visual science
|December 9, 2024
PubMed
概括

虹膜在初级视角闭眼眼 (PACG) 病变发生过程中发挥着关键作用. 已发现的虹膜特异变体影响基因表达和细胞骨组织,为PACG风险因素提供了新的见解.

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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